Mathematics is the study of numbers, Quantity, Space, structure, and change. Mathematics is used throughout the world as an essential tool in many fields, including Natural science, Engineering, Medicine, and the Social sciences. Applied mathematics, the branch of mathematics concerned with application of mathematical knowledge to other fields, inspires and makes use of new mathematical discoveries and sometimes leads to the development of entirely new mathematical disciplines, such as Statistics and Game theory. Mathematicians also engage in Pure mathematics, or mathematics for its own sake, without having any application in mind. There is no clear line separating pure and applied mathematics, and practical applications for what began as pure mathematics are often discovered.